Panama Canal Zone Vacations from $901

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

The Latest Panama Canal Zone vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel Riu Plaza Panama
Central Hotel Panama Casco Viejo
Megapolis Hotel Panamá
Casa Lefevre By Wynwood House
Casa Mallet by Wynwood House
Don't see what you're looking for?
See all available trips from Columbus to Panama Canal Zone
View all trips

Where to stay in Panama Canal Zone

Find the best Panama Canal Zone areas and neighborhoods for the activities you enjoy most. Learn more about Panama Canal Zone

Discover the most popular places to visit in Panama Canal Zone

Panama Canal Zone Hotel Deals

Radisson Hotel Panama Canal

Radisson Hotel Panama Canal

4.5 out of 5
Amador Avenue & Van Hook Street Panama City Panama
$86 nightly
The price is $94 total per night from Jun 4 to Jun 5
$94 total
Jun 4 - Jun 5
Total with taxes and fees
Radisson Hotel Panama Canal
Marriott Panama Hotel

Marriott Panama Hotel

4 out of 5
Roosevelt Ave., Allbrook Mall Panama City Panama
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $167 total per night from May 31 to Jun 1
$167 total
May 31 - Jun 1
Total with taxes and fees
Marriott Panama Hotel
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
$138 nightly
The price is $151 total per night from May 31 to Jun 1
$151 total
May 31 - Jun 1
Total with taxes and fees
9/10 Wonderful! (5,464 reviews)
"Excellent hotel with very helpful staff 5 stars!!!"

Reviewed on May 22, 2026

Hotel Riu Plaza Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Panama Canal Zone Vacation Packages

Panama Canal Zone Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Tocumen Intl. Airport (PTY)

More vacations you might like

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.